I would've loved it if Four had incorporated settlements into the progression of the story. Make the "Evil" faction some tribal group who wants to make sure that society can never get to the point where it can nuke itself again. They sure love saying War Never Changes don't they?
Sorry to keep mentioning it, but besides for my hope that they contracted another studio to make the game, what's the point of using the old Pipboy design?
Not saying that, Bethesda is kinda blase to aesthetics from the Black Isle games, which makes me think they might have another studio working on this; or at least a team with some fresh blood.