I'm on timescale 2 or 4, can't remember, and haven't had any problems yet. Then again, if certain content is just failing to start, I suppose I wouldn't notice that.
Perhaps the one side effect is the Talon Mercenaries coming after me. I'm level 11, and from diffusing the Bomb and telling Burke to scram at level 1 or 2, I've only had 1 encounter with the mercs. This being my first playthrough, I can't say if that is low or not. From what people have said, it does seem low though.