Here's an idea... Everyone remembers Fallout 2, where you ended up carrying dozens of doses of chems around and never using them... I'd like to see more chems, and more places where you could use them. Some Chems could have interesting effects not otherwise achievable (I.E. Buffout became nearly useless when you got Powered Armor.) Furthermore, I'd like to see possible side effects like interaction; and have them come into play in a real way (you could get addicted to chems, but I always just reloaded). For Example you could have an area contaminated both radiologically and biologically, but you couldn't take the pill for both because doing so would [nullify an effect, make you ill, drop a stat that you'd need inside the area, simply kill you, etc]. Thus the player would have to either suck up one thing, or somehow make himself immune (by hunting down an environment suit, or a radiation suit, or something like that.)